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ビタミンK 改訂版 医学・生物学領域における新展開

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ビタミンK 改訂版 医学・生物学領域における新展開
書籍名ビタミンK 改訂版 医学・生物学領域における新展開
出版社メディカル・ジャーナル社
発行日1994-04-20
著者岩永貞昭(監修) 斎藤英彦(監修) 松田道生(監修)
ISBN4944012012
ページ数 515
版刷巻号第2版第1刷

メディカルブックオンラインセンター

冊子の書籍はこちら

「ビタミン K」と題してその初版を送り出したのは今から6年前のことである。今回、とくに臨床面での情報を大幅に補填、改稿して同じタイトル「ビタミン K」のもとに改訂版を上梓する運びになった。(「まえがき」より)

目次

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執筆者


まえがき


目次


カートに入れる

OPEN  I. ビタミンK研究の歴史
810 円

1) H. Damの発見

2


2) ビタミンK1, K2, ジクマロールの分離と構造

2


3) 異常プロトロンビンの発見

3


4) 新しいアミノ酸Glaの発見

4


5) ビタミンK依存性カルボキシラーゼの発見

5


6) ビタミンK依存性カルボキシラーゼとビタミンK - 2, 3 - エポキシダーゼの連動

6


7) 肝臓におけるビタミンKの代謝

7


カートに入れる

OPEN  II. ビタミンKの構造・分布・代謝
810 円

1. ビタミンKの構造

9


1) ビタミンK同族体

9


2) 性状および構造

11


2. ビタミンKの測定法

14


1) 定量前操作

14


2) 検出法

18


3) 血漿・母乳中内因性ビタミンK ( PK, MK - 4?MK - 10 ) 分析の実際

26


3. 自然界の分布 ( ビタミンK2 )

33


1) 名称

33


2) 細菌によるK2の産生

33


3) 種々な細菌中のK2分布

35


4) ヒト生体試料中のK2の分布

37


5) 食品中のK2含量

38


4. 生体内動態

41


A. 動物

41


1) 吸収および血中濃度

41


2) 組織および細胞内分布

44


3) 代謝

49


4) 排泄

54


B. ヒト

63


1) 成人における血中未変化体の薬物動態

63


2) 新生児における血中薬物動態

67


3) 吸収・代謝・排泄

69


4) ビタミンKサイクルと抗凝血薬

74


5) 内因性ビタミンKレベル

75


カートに入れる

OPEN  III. ビタミンKの作用機序
810 円

1) ビタミンK依存性蛋白質

82


2) ビタミンK依存性カルボキシラーゼの性状

84


3) ビタミンK依存性カルボキシラーゼの作用機作

84


4) ビタミンK依存性カルボキシラーゼの基質特異性

87


5) ビタミンKの代謝

88


カートに入れる

OPEN  IV. ビタミンK依存性凝固因子の生合成とプロセシング
810 円

1) γ - カルボキシル化反応はいつどこで進行するのか ?

95


2) γ - カルボキシル化はビタミンK依存性凝固因子の分泌に必要か ?

96


3) ビタミンK依存性凝固因子のAsn - 結合型糖鎖は細胞内輸送と活性発現において重要な役割を演じている

97


4) プロセシングプロテアーゼ候補の最有力はKex2類似プロテアーゼである

101


カートに入れる

OPEN  V. ビタミンK依存性蛋白質とその機能
810 円

1. 凝固因子

109


A. プロトロンビンファミリーの構造

109


1) プロトロンビン

121


2) VII因子

131


3) IX因子

149


4) X因子

157


5) プロテインC

169


6) プロテインS

176


7) プロテインZ

181


B. Glaドメインの機能

184


1) Ca2 + 結合能とリン脂質結合能におけるGlaドメインの機能

186


2) 補助因子との複合形成におけるGlaドメインの機能

188


3) Glaドメインの血液凝固における生理的役割

188


4) Glaドメインの特異性

190


C. γ - カルボキシグルタミン酸 ( Gla ) およびβ - カルボキシアスパラギン酸 ( Asa ), アミノマロン酸 ( Ama ) 残基を含む蛋白質成分

194


1) ラット腎皮質蛋白質

195


2) ラット大動脈蛋白質

195


3) コノトキシンGV

195


4) ニワトリ精子蛋白質

196


5) E. coliリボゾーム蛋白質

196


D. γ - カルボキシグルタミン酸の分析法

198


1) Glaの化学的特性

198


2) Glaの同定法

200


3) Glaの定量法

202


2. 骨のビタミンK依存性蛋白質

218


1) BGPならびにMGPの構造と機能

219


2) BGPならびにMGPの生合成

224


3) 血液中のBGPとMGP

227


4) 骨代謝とBGPならびにMGP

230


3. ウイルス活性化酵素としてのX因子

238


1) ニワトリ胚VAPの単離精製とそのFXaとの構造的, 機能的相同性

240


2) VAPのcDNAクローニングと一次構造の決定

243


3) FXの異所性発現とウイルストロピズム

243


カートに入れる

OPEN  VI. ビタミンKの臨床
810 円

ビタミンK依存性蛋白質の欠乏症

255


1) 先天性欠乏症および異常症

255


2) 肝不全

256


3) ビタミンK欠乏症

257


4) インヒビターによるビタミンK依存性蛋白の不活性化

261


1. 先天性のビタミンK依存性蛋白質の欠乏症

263


1) IX因子欠乏症および異常症 - 血友病B

263


2) プロトロンビン欠乏症および異常症

277


3) X因子, VII因子欠乏症および異常症

290


4) 先天性プロテインC欠損症およびプロテインC異常症

299


5) プロテインS欠乏症

312


2. 抗生物質とビタミンK

321


1) 抗生物質投与中のビタミンK欠乏

321


2) 腸内細菌とビタミンK

326


3) MTTとビタミンK

328


4) 抗生物質投与中のビタミンK欠乏の予防

331


3. 新生児および乳児のビタミンK欠乏症

336


1) 新生児ビタミンK欠乏性出血症 ( primary hemorrhagic disease of the newborn, PHDN )

336


2) 乳児ビタミンK欠乏性出血症

341


4. 妊娠とビタミンK

350


1) ビタミンK依存性凝固蛋白質の妊娠による変動

350


2) 妊娠維持機構とビタミンK依存性凝固蛋白質

358


3) 胎児のビタミンK依存性凝固蛋白質

362


5. 乳児ビタミンK欠乏症の全国調査

367


1) 発症頻度の変遷

367


2) 性別発症頻度

368


3) 年齢別発症頻度

368


4) 季節別発症頻度

370


5) 地域別発症頻度

371


6) 栄養法

371


7) 出血部位

372


8) 転帰

372


9) ビタミンK剤予防投与の有無

372


10) 二次性乳児ビタミンK欠乏性出血症の基礎疾患

374


6. 特発性乳児ビタミンK欠乏症 - 乳児特発性頭蓋内出血 -

375


1) 歴史

375


2) 病因論

381


7. 肝疾患での尿中γ - カルボキシグルタミン酸の変動について

389


1) Glaの測定について

390


2) 尿中Glaのレベルと肝疾患

391


8. 肝癌とビタミンK依存性因子

401


1) 肝細胞癌における異常ビタミンK依存性凝固因子および阻止因子の産生

401


2) 肝細胞癌によるビタミンK依存性凝固因子の量的変化

403


9. 肝癌とPIVKA - II

408


1) PIVKA - II

408


2) PIVKA - IIの測定方法

409


3) PIVKA - IIと肝芽腫, 肝細胞癌

412


10. Bone Gla Proteinと骨疾患

420


1) BGPの精製とBGPのRIA

423


2) 血清中BGP値の性差・加齢変化および正常域

425


3) 各種疾患における血清中BGP値の変動

430


11. BGPと内分泌代謝疾患

455


1) 骨芽細胞のBGP合成に関与するホルモン

455


2) その他の因子

456


3) 内分泌代謝疾患と血中BGP値

456


4) 各種内分泌疾患における血中ビタミンK値

458


5) 副甲状腺疾患

458


6) 甲状腺疾患

461


7) その他

464


12. 糖尿病性骨減少症

470


1) 糖尿病性骨減少症

470


2) 糖尿病性骨減少症の病態

471


3) 糖尿病性骨減少症の病因

472


13. BGPと腎疾患

480


1) 腎機能とBGP

480


2) 腎不全患者とBGP

481


3) 腹膜透析患者とBGP

484


4) 糖尿病性腎症透析患者とBGP

485


5) 副甲状腺切除の影響

487


6) 移植の影響

488


OPEN  索引

略語一覧

497


奥付


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参考文献

参考文献のリンクは、リンク先の都合等により正しく表示されない場合がありますので、あらかじめご了承下さい。

参考文献を表示
I. ビタミンK研究の歴史
P.8 掲載の参考文献
* Suttie J. W. : Vitamin K-dependent carboxylase.

* Ann. Rev. Biochem., 54 : 459 (1985), NY : Academic.

II. ビタミンKの構造・分布・代謝
P.12 掲載の参考文献
1) 平山健三, 平山和雄, 訳著 : "有機化学, 生化学命名法 (下) ", 化学領域増刊号, 131号, p164-168, 南江堂, 東京 (1981)

3) McCormik D. B. and Wright L. D. ed. : "Methods in Enzymology" Vol. XVIII, part C, p407-562, Academic Press, New York (1971)

4) Collins M. D. and Jones D. : Distribution isoprenoid quinone structural types in bacteria and their taxonomic implications. Microbiol. Rev., 45 : 316 (1981)

5) Beau S., Azerard R. and Ledrer E. : Isolation and characterization of the dihydromenaquinones of Mycobacteria and Cornebacteria. Bull. Soc. Chim. Biol., 48 : 569 (1966)

6) Azerard R. and Cyrot M. D. : Synthesis of two dihydrofarnesyl menaquinones related to vitamine K2 (45) from Mycobacterium phlei. Bull. Soc. Chim. France, 3740 (1965)

7) Baum R. H. and Dolin M. I. : Isolation of 2-solanosyl-1, 4-naphthoquinone from Streptococcus faecatis. J. Biol. Chem., 240, 342 (1965)

10) a) Windholz M. ed. : "The Merk Index" 10th ed. monograph No.5651, Merk & Co., Inc. Rahway, New Jersy (1983). b) Ibid. No.5647. c) Ibid. No.9837. d) Ibid. No.9838. e) Ibid. No.9839.

13) Mayer H. and Isler O. : "The vitamine" ed. by Schrell Jr. W. H. and Harris R. S., Vol.3, p418, Academic Press, New York (1971)

P.29 掲載の参考文献
6) Dialameh G. H. and Olson R. E. : Gas-liquid chromatography of phythyl ubiquinone, vitamin E, vitamin K1 and homologs of vitamin K2. Anal. Biochem., 32 : 263 (1969)

8) 篠光正, 山城智子, 山田浩司, 森豊, 里忠, 河部靖, 岡田和夫 : 健康人におけるMenaquinone-4製剤投与後の血漿中Menaquinone-4の定量. 薬学雑誌, 102 : 651 (1982)

11) Lefevere M. F., De Leenheer A. P., Claeys A. E., Claeys I. V. and Steyaert H. : Multidimensional liquid chromatography : A breakthrough in the assessment of physiological vitamin K levels. J. Lipid. Res., 23 : 1068 (1982)

25) 阿部皓一, 広島修, 石橋恭子, 大前雅彦, 河部靖, 勝井五一郎 : 高速液体クロマトグラフィーによる生体中のフィロキノンおよびメナキノン-4の螢光定量. 薬学雑誌, 99 : 192 (1979)

26) 広島修, 阿部皓一, 池谷理, 大前雅彦, 河部靖 : 螢光反応検出を利用した高速液体クロマトグラフィーによる生体中のフィロキノン 2, 3-エポキシドおよびメナキノン 2, 3-エポキシドの定量. 薬学雑誌, 99 : 1007 (1979)

27) 白幡聡, 中村外士雄, 小松啓子, 椎木みどり, 萱蔦成美 : 血清ならびに糞便中のビタミンK (phylloquinoneおよびmenaquinone-4) の測定成績-とくに新生児と成人の比較. 医学のあゆみ, 129 (1) : 21 (1984)

28) 佐藤孝義, 八尋政利, 下田幸三, 浅居良輝, 浜本典男 : 高速液体クロマトグラフィーによる乳, 粉乳および植物油脂中のビタミンKの定量法. 日本栄養・食糧学会誌, 38 : 451 (1985)

32) (a) 篠光正 : ビタミンKの測定法と血中濃度. ビタミンK機能セミナー (第2回) 発表 (1985) (b) Shino M. : Determination of endogenous vitamin K (phylloquinone and menaquinone-n) in plasma by high-performance liquid chromatography using platinum oxide catalyst reduction and fluorecence detection. Analyst, 113 : 393 (1988)

35) 白幡聡, 萱蔦成美 : ビタミンKの高感度測定法. Medical Way, 2 : 71 (1985)

36) 篠光正 : unpublished data

37) Collins M. D. and Jones D. : Destribution of isoprenoid quinones structural types in bacteria and their taxonomic implications. Microbiol. Rev., 45 (2) : 316 (1981)

39) Lefevere M. F. L., Claey A. E. and Leeheer A. P. : Vitamin K : Phylloquinone and menaquinones. Chromatogr. Sci., 31 : 201 (1985)

P.39 掲載の参考文献
1) Bentley R. and Meganathan R. : Biosynthesis of vitamin K (menaquinone) in bacteria. MicrobioL Rev., 46 : 241, (1982).

2) 谷吉樹 : ビタミンK生合成研究-最近の進歩. ビタミン. 61 : 574, (1987).

3) Taber H. (Suttie J. W.) : Functions of vitamin K2 in microorganisms. In : Vitamin K metabolism and vitamin K-dependent proteins. p.177. University Park Press, Baltimore (1980).

4) Van Buskirk J. J., Low M. and Kirsch W. M. (Suttie J. W.) : Growth-related changes in the carboxylation of E. coli ribosomes. In : Vitamin K metabolism and vitamin K-dependent proteins. p.274, University Park Press, Baltimore (1980).

6) Collins M. D. and Jones D. : Distribution of isoprenoid quinone structural types in bacteria and their taxonomic implications. Microbiol. Rev., 45 : 316, 1981.

7) 白幡聡, 中村外士雄 : ヒト生体試料中のvitamin K1 (phylloquinone) およびvitamin K2 (menaquinones) 同族体の個別測定, 血液と脈管 16 : 395, (1985).

10) Uchida K. and Komeno T. : Relationships between dietary and intestinal vitamin K, clotting factor levels, plasma vitamin K, and urinary Gla. In : Current advances in vitamin K research (edited by Suttie J. W.) Elsevier (New York), p.477 (1988).

14) 白幡聡 (大西鐘壽, 編) : 母乳栄養とビタミンK, 周生期薬物療法 (小児科MOOK 36), p.248, 金原出版, 東京 (1985).

15) 坂野俊行, 野津本茂, 長岡忠義, 森本厚, 藤本恭子, 増田佐智子, 鈴木由紀子, 平内三政 : 蛍光検出高速液体クロマトグラフィー法による食品中のビタミンK類の測定. ビタミン, 62 : 393 (1988).

P.58 掲載の参考文献
1) 森内幸子, 太田原洋子 : ビタミンKの生合成と代謝. ビタミン学 (I). p.251, 東京化学同人, (1980)

2) Robert E. O. : The function and metabolism of vitamin K. Ann. Rev. Nutr., 4 : 281 (1984)

3) Bell R. G. : Metabolism of vitamin K and prothrombin synthesis : anticoagulants and the vitamin K-epoxide cycle. Fed. Proc., 37 : 2599 (1978)

5) Mann J. D., Mann F. D. and Bollman J. L. : Hypoprothrombinemia due to loss of intestinal lymph. Am. J. Physiol., 158 : 311 (1949)

6) Lengsfeld H., Gallo-Torres H. and Rietz P. : Lipoprotein-mediated transport of phylloquinone in the thoracic duct lymph of rats. EXperientia, 27 : 728 (1971)

7) 但野恭一, 篠光正, 大和千靱 : メナキノン-4 (K2) の代謝. 第一回ビタミンK機能セミナー抄録集. p.22 (1984)

8) Aso Y., Mishima K., Arisaka T. and Kitagawa H. : 薬物のリンパ吸収. 第1回薬物代謝と薬効・毒性シンポジウム要旨集. p.21 (1969)

9) Hollander D. : Vitamin K1 absorption by everted intestinal sacs of the rat. Am. J. Physiol., 225 : 360 (1973)

10) Hollander D., Rim E. and Muralidhara K. S. : Vitamin K1 intestinal absorption in vivo : influence of luminal contents on transport. Am. J. Physiot., 232 : E69 (1977)

11) Hollander D. and Rim E. : Vitamin K2 absorption by rat everted small intestinal sacs. Am. J. Physiol., 231 : 415 (1976)

12) Hollander D., Rim E. and Ruble Jr. P. E. : Vitamin K2 colonic and ileal in vivo absorption : bile, fatty acids, and pH effects on transport. Am. J. Physiot., 233 : E124 (1977)

13) Hollander D., Muralidhara K. S. and Rim E. : Colonic absorption of bacterially synthesized vitamin K2 in the rat. Am. J. Physiol., 230 : 251 (1976)

14) Hollander D., and Truscott T. C. : Mechanism and site of vitamin K-3 small intestinal transport. Am. J. Physiol., 226 : 1516 (1974)

15) Hollander D. and Truscott T. C. : Colonic absorption of vitamin K-3. J. Lab. Clin. Med., 83 : 648 (1974)

17) Komai M., Shirakawa H., Sato H. and Kimura S. : Establishment of primary vitamin K deficient mice and its use for menaquinones metabolism. Vitamins (Japan), 63 : 229 (1989)

18) Kinoshita K., Katayama K., Horie T., Matsuura T., Takamatsu T., Tsutsumi J., Yamato C., Fujita T., Miyao K., Baba, S. and Konishi T. : Studies on metabolism of menaquinone-4. 1. Absorption, tissue distribution, excretion in rats and guinea-pigs. Oyo Yakuri-Pharmacometrics., 5 : 505 (1971)

20) Breckenridge A. M., Park B. K., and Wilson A. C. : The effect of phenobarbitone on the phannacokinetics and phamacodynamics of vitamin K in the rabbit. Br. J. Pharrmacol., 77 : 558p (1982)

21) Horiuchi Y., Kikuchi M., Hirayama F., Uekama K., Ueno M. and Ijitsu T. : Improvement of bioavailability of menaquinone-4 by dimethyl- β-cyclodextrin complexation following oral administration. Yakugaku Zasshi, 108 : 1093 (1988)

23) Thierry M. J., Hennodson M. A. and Suttie J. W. : Vitamin K and warfarin distribution and metabOlism in the warfarin-resistant rat. Am. J. Physiol., 219 : 854 (1970)

24) Hirate J., Horikoshi I., Watanabe J., Tadano K., Yamato C. and Fujita T. : Disposition of menaquinone-4 following intravenous and oral administration to rats. Oyo Yakuri-Pharmacometrics., 29 : 775 (1985)

27) Knauer T. E., Siegfried C., Willingham A. K. and Matschiner J. T. : Metabolism and biological activity of cis-and trans-phylloquinone in the rat. J. Nutr., 105 : 1519 (1975)

32) Wiss O. and Gloor U. : Absorption, distribution, storage, and metabolites of vitamin K and related quinones. Vitam. Horm., 24 : 575 (1966)

33) Watanabe M., Toyoda M., Imada I. and Morimoto H. : Ubiquinone and related compounds. XXVI. The urinary metabolites of phylloquinone and α-tocopherol. Chem. Pharm. Bull., 22 : 176 (1974)

35) Matschiner J. T. and Bell R. G. : Metabolism and vitamin K activity of cis phylloquinone in rats., J. Nutr., 102 : 625 (1972)

37) Miura M., Hiraike H., Kimura M. and Itokawa Y. : Conversion of vitamin K1 into menaquinone-4 in rat brain and plasma. Vitamins (Japan), 64 : 459 (1990)

39) Dialameh G. H., Taggart W. V., Matschiner J. T. and Olson R. E. : Isolation and characterization of menaquinone-4 as a product of menadione metabolism in chicks and rats. Internat. J. Vit. Nutr. Res., 41 : 391 (1971)

40) Dialameh G. H., Yekundi K. G. and Olson R. E. : Enzymatic alkylation of menaquinone-0 to menaquinones by microsomes from chick liver. Biochim. Biophys. Acta, 223 : 332 (1970)

42) Losito R., Owen Jr. C. A. and Flock E. V. : Metabolic studies of vitamin K1-14C and menadione-14C in the normal and hepatectomized rats. Thromb. Diath. Haemorrhag., 19 : 383 (1968)

47) Park B. K., Leck J. B., Wilson A. C., Serlin M. J. and Breckenridge A. M. : A study of the effect of anticoagulants on [3H] vitamin K1 metabolism and prothrombin complex activity in the rabbit. Biochem. Pharmacot., 28 : 1323 (1978)

51) 政田幹夫, 中西邦夫, 灘井種一 : 脂溶性ビタミンの種類と生体内動態. 薬局, 35 : 1019 (1984)

53) Fasco M. J., Hildebrandt E. F. and Suttie J. W. : Evidence that warfarin anticoagulant action involves two distinct reductase activities. J. Biol. Chem., 257 : 11210 (1982)

58) Hamulyak K., de Boer-van den Berg M. A. G. and Thijssen H. H. W. : The placental transport of [3H] vitamin K1 in rats. Br. J. Haematot., 65 : 335 (1987)

59) Guillaumont M. J., Durr F. M., Combet J. M., Gueho A. G., Fournier B. M., Sann L., Leclercq M. A. and Frederich A. H. : Vitamin K1 diffusion-across the placental barrier in the gravid female rat. Dev. Pharmacol. Ther., 11 : 57 (1988)

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4) 高松富夫, 松浦恒雄, 木下健策, 堤淳三, 片山幸一, 大和千靱, 堀江透, 藤田孟, 宮尾興平 : Menaquinone-4の代謝に関する研究 (第3報) ヒトにおけるMenaquinone-4の経口または静脈内投与時の血中濃度測定. 応用薬理, 5 (4) : 525 (1971)

5) 森下亘通, 小川正, 崎田二郎, 篠光正, 山城智子, 山田浩司, 森豊, 河崎直久, 岡田和夫 : Vitamin K2シロップ投与後の健康成人男子におけるK2血中濃度推移. 基礎と臨床, 15 (4) : 221 (1981)

6) 篠光正, 山城智子, 山田浩司, 森豊, 里忠, 河部靖, 岡田和夫 : 健康人におけるMenaquinone-4製剤投与後の血漿中Menaquinone-4の定量. 薬学雑誌, 102 (7) : 651 (1982)

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10) 篠光正ら : 健康人におけるK1製剤投与後の血中未変化体濃度. 未発表.

11) 鈴木重統, 白川光一, 真木正博, 寺尾俊彦 : 新生児に対するビタミンK投与とその吸収. 産婦人科・新生児血液, 4 : 357 (1980)

13) Blomstrand R. and Forsgren L. : Vitamin K1- 3H in man-Its intestinal absorption and transport in the thoracic duct lymph. Int. Z. Vitaminforsch., 38 : 45 (1968)

14) Gueho A, Guillaumond M., Leclerq M., Durr F. and Frederich A. : Pharmacokinetics of vitamin K1 in the child on total parenteral nutrition. J. Pharmacol., 16 (4) : 544 (1985)

21) Bjornsson. T. D., Meffin P. J., Swezey S. E. and Blaschke T. F. : Effects of clofibrate and warfarin alone and in combination on the disposition of vitamin K1. J. Pharm. Exp. Ther., 210 (3) : 322 (1979)

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25) Haustein K. O. : Interaction between pkenprocoumon and phytomenadion-a pharmacokinetic investigation in healthy volunteers. Zbl. Pharm. 124 (3) : 130 (1985)

27) 篠光正 : ビタミンKの測定法と血中濃度. ビタミンK機能セミナー (第2回) : 15 (1985)

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III. ビタミンKの作用機序
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25) Knobloch J. E. and Suttie J. W. : Vitamin K-dependent carboxylase. Control of enzyme activity by the "propeptide" region of factor X. J. Biol. Chem., 262 : 15334 (1987)

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IV. ビタミンK依存性凝固因子の生合成とプロセシング
P.105 掲載の参考文献
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24) Hase S., Kawabata S., Nishimura H., Takeya H., Sueyoshi T., Miyata T., Iwanaga S., Takao T., Shimonishi Y., and Ikenaka T. : A new trisaccharide sugar chain linked to a serine residue in bovine blood coagulaion factors VII and IX. J. Biochem., 104 : 867 (1988)

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V. ビタミンK依存性蛋白質とその機能
P.119 掲載の参考文献
1) 森田隆司, 岩永貞昭, 他 : 特集, γ-カルボキシグルタミン酸含有蛋白. 代謝, 19 : No.9 (1982)

2) 鈴木宏治 : 燐脂質相における凝固の活性化反応. 臨床病理, 33 : 966 (1985)

3) 鈴木宏治, 出屋敷喜宏 : 凝固・線溶因子の分子構造と機能. 臨床病理 特集第70号 : p.13 (1987)

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P.129 掲載の参考文献
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17) Liu L-W., Ye J., Johnson A. E and Esmon C. T. : Proteolytic formation of either of the two prothrombin activation intermediates results in formation of a hirugen-binding site. J. Biol. Chem., 266 : 23632 (1991)

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20) 関屋富士男, 森田隆司 : トロンビンレセプター, Annual Review血液1994, 高久史磨, 宮崎澄雄, 斎藤英彦, 溝口秀昭編集, 中外医学社, 東京, 印刷中.

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9) Wu S. M., Cheung W. -F., Frazier D., and Stafford D. W : Cloning and Expression of the cDNA for Human γ-Glutamyl Carboxylase. Science, 254 : 1634 (1991)

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15) Price PA, Poser J. W. and Raman N. : Primary structure of the γ-carboxyglutamic acid-containing protein from bovine bone. Proc. Natl. Acad. Sci. U. S. A, 73 : 3374 (1976)

16) Otawara Y., Hosoya N., Moriuchi S., Kasai H. and Okuyama T. : The NH2- terminal amino acid sequence of γ-carboxyglutamic acid containing protein from rat cortical bone. Biomed. Res., 2 : 442 (1981)

17) Pan L. C. and Price P. A. : Sequence of the precursor to rat bone γ-carboxyglutamic acid protein that accumulates in warfarin treated osteosarcoma cells. J. Biol. Chem., 260 : 13398 (1985)

18) Price P. A., Otsuka A. S. and Poser J. W. : Characterization of γ-carboxyglutamic acid-containing proteins from bovine and swordfish bone. Primary structure and calcium binding : In calcium binding proteins and calcium function, (Wasserman R. H., et al. eds.) Elsevier/North Holland Inc. Amsterdam, p.333 (1978)

19) Hauschka P. V. and Carr S. A. : Calcium-dependent α-helical structure in osteocalcin. Biochemistry, 21 : 2538 (1982)

20) Hauschka P. V. : Osteocalcin and its functional domains, in the chemistry and biology of mineralized tissues, (Butler W. T. ed) EBSCO Media, Birmingham, p.149 (1985)

21) Mundy G. R. and Poser J. W. : Chemotactic activity of the γ-carboxyglutamic acid containing protein in bone. Calcif. Tis. Int., 35 : 164 (1983)

22) 河野敬一 : オステオカルシンについて. ビタミンK機能セミナー (第一回) メディカルジャーナル社, 東京, p.158 (1985)

23) Poser J. W. and Price P. A. : A method for decarboxylation of γ-carboxyglutamic acid in proteins. J. Biol. Chem., 254 : 431 (1979)

24) 森内幸子, 太田原洋子 : γ-カルボキシグルタミン酸含有蛋白の構造と機能. 代謝, 19 : 855 (1982)

25) Price P. A. and Williamson M. K. : Effect of warfarin on bone. J. Biol Chem., 256 : 12754 (1981)

27) Price P. A. and Sloper S. A. : Concurrent warfarin treatment further deduces bone mineral levels in 1, 25-dihydroxyvitamin D3-treated rats. J. Biol. Chem., 258 : 6004 (1983)

28) Price P. A., Lothringer J. W. and Nishimoto S. K. : Absence of the vitamin K-dependent bone protein in fetal rat mineral. Evidence for another γ-carboxyglutamic acid-containing component in bone. J. Biol Chem., 255 : 2938 (1980)

29) Price P. A., Williamson M. K. and Otawara Y. : Characterization of matrix Gla protein, a new vitamin K-dependent protein associated with the organic matrix of bone, in the chemistry and biology of mineralized tissues, (William T. B. ed.) EBSCO media, Birmingham, p.159 (1985)

30) Hauschka P. V., Frenkel J. and DeMuth R. : Presence of osteocalcin and related higher molecular weight γ-carboxyglutamic acid-containing proteins in developing bone. J. Biol. Chem., 258 : 176 (1983)

31) Price P. A., Urist M. R., and Otawara Y. : Matrix Gla-protein, a new γ-carboxyglutamic acid-containing protein which is associated with the organic matrix of bone. Biochem. Biophys. Res. Commun., 117 : 765 (1983)

32) Price P. A. and Williamson, M. K. : Primary structure of bovine matrix Gla protein, a new vitamin K-dependent bone protein. J. Biol. Chem., 260 : 14971 (1985)

34) Lian J. B. and Heroux K. M. : In vitro studies of osteocalcin biosynthesis in embryonic chick bone cultures, in vitamin K metabolism and vitamin K-dependent proteins, (Suttie J. W. ed.) University Park Press, Baltimore, p.245 (1980)

35) Nishimoto S. K. and Price P. A. : Proof that the γ-carboxyglutamic acidcontaining bone protein is synthesized in calf bone : Comparative synthesis rate and effect of coumadin on synthesis. J. Biol. Chem., 254 : 437 (1979)

36) Nishimoto S. K. and Price P. A. : Secretion of the vitamin K-dependent protein of bone by rat osteosarcoma cell. J. Biol. Chem., 255 : 6579 (1980)

38) Nishimoto S. K. and Price P. A. : The vitamin K-dependent bone protein is accumulated with in cultured osteosarcoma cells in the presence of the vitamin K antagonist warfarin. J. Biol. Chem., 260 : 2832 (1985)

39) Pan L. C. and Price P. A. : The effect of transcriptional inhibitors on the bone γ-carboxyglutamic acid protein response to 1,25-dihy-droxyglutamin-D3 in osteosarcoma cells. J. Biol. Chem., 259 : 5844 (1984)

40) Pan L. C. and Price P. A. : The propeptide of rat bone γ-carboxyglutamic acid protein shares homology with other vitamin K-dependent protein precursors. Proc. Natl. Acad. Sci. USA, 82 : 6109 (1985)

41) Celeste A. J., Rosen V., Buecker J. L., Kriz R., Wang E. A. and Wozney J. M. : Isolation of the human gene for bone Gla protein utilizing mouse and rat cDNA clones. The EMBO J. 5 : 1885 (1986)

43) Jorgensen M. J., Cantor A. B., Furie B. C., Brown C. L., Shoemaker C. B. and Furie B. : Recognition site directing vitamin K-dependent γ-carboxylation residues on the propeptide of Factor IX. Cell, 48 : 185 (1987)

44) Price P. A., Fraser J. D., Metz-Virca G. : Molecular cloning of matrix Gla protein ; Implications for substrate recognition by the vitamin K-dependent γ-carboxylase. Proc. Natl. Acad. Sci. USA, 84 : 8335 (1987)

46) Otawara Y. and Price P. A. : Developmental appearance of matrix Gla protein during calcification in the rat. J. Biol. Chem., 261 : 10828 (1986)

48) 森内幸子, 太田原洋子, 細谷憲政 : 骨のビタミンK依存性蛋白質に関する最近の知見, ビタミン, 57 : 247 (1983)

49) Price P. A., Williamson M. K. and Lothringer J. W. : Origin of the vitamin K-dependent protein found in plasma and its clearance by kidney and bone. J. Biol. Chem., 256 : 12760 (1981)

50) Gundberg C. M., Lian J. B. and Gallop P. M. : Measurements of γ-carboxyglutamate and circulating osteocalcin in normal children and adults. Clin. Chim. Acta, 128 : 1 (1983)

51) Otawara Y., Hosoya N. and Moriuchi S. : Effect of aging and castration on the changes in the levels of bone γ-carboxyglutamic acid-containing protein in bone and serum of female rat. J. Nutr. Sci. Vitaminol., 29 : 249 (1983)

52) Otawara Y. and Price P. A. : Secretion of matrix Gla protein from bone to serum, manuscript is under preparation.

54) Lian J. B., Glimcher M. J., Roufosse A. H., Hauschka P. V., Gallop P. M., Solal L. C and Reit B. : Alterations of the γ-carboxyglutamic acid and osteocalcin concentrations in vitamin D-deficient chick bone. J. Biol. Chem., 257 : 4999 (1982)

55) Tsutsumi C., Hosoya N. and Moriuchi S. : The changes of bone γ-carboxyglutamic acid-containing protein in bone and serum of developing chick. J. Nutr. sci. vitaminol., 29 : 643 (1983)

56) Tsutsumi C., Hosoya N. and Moriuchi S. : The effect of 1, 25-dihydroxycholecalciferol on the changes of bone γ-carboxyglutamic acidcontaining protein in bone and serum of developing chick. J. Nutr. Sci. Vitaminol., 31 : 21 (1985)

57) Tsutsumi C., Hoshiba K., Moriuchi S., Orimo H. and Hosoya N. : Regulatory effect of calcium-regulating hormones on the synthesis and/or secretion of bone γ-carboxyglutamic acid-containing protein in chick embryonic calvaria in vitro. J. Nutr. Sci. Vitaminol., 32 : 157 (1986)

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1) 飯塚敦夫, 長尾大, 三間屋純一 : 幼若乳児におけるプロトロビン複合体欠乏による重篤出血傾向-ビタミンK欠乏症-小児科診療, 38 : 1482 (1975)

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